MIMIC: A Multi-centre Cohort Study Evaluating the role of Inflammatory Markers in Patient’s Presenting with Acute Ureteric Colic
Service Evaluation Project
A multi-centre service evaluation of the management of patients presenting with acute ureteric Colic (MIMIC)
Background
Admission to A&E is very common with over 750,000 patients admitted every year in the EU. Current practice in admitting and managing this condition is not clearly known.
Aim and Objective
We would like to assess the intervention rates of patients who are admitted with acute ureteric colic and assess which tests are commonly done in their work up. Of interest is what role clinicians give to inflammatory markers in their management of patients and what imaging tests and interventions were carried out.
Methods
Multi-centre national service evaluation in a 1000 patients who have previously been admitted with acute ureteric colic will have data recorded of the date of their first CT scan, the admission details including blood test results and follow up details including whether intervention or imaging was carried out. This is to be collected for patients who have already been managed by their hospital team and whose details are already stored in the trust imaging system and electronic records.
The project meets the criteria for as a service evaluation project as per the HRA online tool (see attachment below) and has also been evaluated by the R&D department at University College London Hospital and deemed as non-research.
This service evaluation will be carried out at a number of hospital sites. It is hoped that observing intervention practice and looking at variation in practice between sites may help us identify areas for service improvement.
Local Hospital Trust data management policies will be followed. No patient identifiable data will leave the original site. If any communications containing patient identifiable information are deemed necessary they will only be conducted via nhs.net email accounts or Trust email accounts.
Primary Objective
- To examine whether or not there is any evidence of regional variation within the UK in the proportion of acute ureteric colic patients who undergo intervention.
Secondary Objectives
- To determine the level of association, if any, between white blood cell count (WBC count) and subsequent intervention in patients who present with acute ureteric colic.
Deliverables for Audit Departments
In patients admitted with ureteric colic:
- Intervention rate
- Intervention type
- Timing
- Inflammatory marker levels at presentation
Pilot has been completed
Approved by 6 Audit Departments and carried out in 120 Patients from 6 UK Centers
- Taimur Shah Whittington Hospital, London
- Veeru Kasivisvanathan University College Hospital, London
- Ben Lamb University College Hospital, London
- Sophia Cashman Peterborough City Hospital, Cambridgeshire
- Karl Pang Sheffield Teaching Hospitals, Sheffield
- Marcus Cumberbatch Sheffield Teaching Hospitals, Sheffield
- Arjun Nambiar Cumberland Infirmary, Cumbria
- James Akman St Bartholemew’s Hospital, London
MIMIC Poster
MIMIC Achievements
Taimur Shah – Lead of MIMIC and Won Best Poster in session at EAU 2017
Chuanyu Gao – Won Best Presentation at SURG 2017
Kevin Gallagher – runner up for BJS/ASiT methodology prize, Nov 2017
Taimur Shah – won best in session at EAU 2018, Copenhagen, March 2018
List of MIMIC Achievements
| Date | Type | Achievement | Evidence |
| April 2018 | Prize | Best ePoster, BAUS 2018, Liverpool, UK | Link |
| April 2018 | Prize | ASIT/SARS Winner 2018, Edinburgh, UK | Link |
| March 2018 | Prize | Best in Session at European Association of Urology (EAU) 2018 Annual Meeting, Copenhagen, Denmark | Link |
| March 2018 | Poster Presentation | European Association of Urology (EAU) 2018 Annual Meeting, Copenhagen, Denmark | Link |
| October 2017 | Publication | MIMIC Study Protocol Published in International Journal of Surgery Protocols | Link
Cite as: A multi-centre cohort study evaluating the role of inflammatory markers in patient’s presenting with acute ureteric colic (MIMIC) (2017) T. Shah et al. International Journal of Surgery Protocols 6 (2017) 1–4. |
| November 2017 | Prize | Runner up for BJS/ASiT Methodology Prize, at National Research Collaborative Meeting 2017, Birmingham | N/A |
| July 2017 | Prize | Best Presentation at Specialist Urology Registrars’ Group 2017 Annual Meeting | Link |
| April 2017 | Prize | Best National Research Collaborative Prize – Birmingham Surgical Trials Consortium Prize (BiSTC) at ASIT Conference 2017, Bournemouth, UK | Link |
| March 2017 | Prize | Best in Session at European Association of Urology (EAU) 2017 Annual Meeting, London, UK | Link |
| October 2017 | Oral Presentation | National Research Collaborative Meeting 2017, Birmingham | N/A |
| October 2017 | Poster Presentations | Society of International Urology (SIU) 2017 Annual Meeting, Lisbon, Portugal | Link |
| September 2017 | Oral Presentations | Irish Society of Urology (ISU) 2017, Cork, Ireland | Link |
| September 2017 | Oral Presentation | World Congress of Endourology (WCE) 2017, Vancouver, Canada | Link |
| July 2017 | Oral Presentation | Specialist Urology Registrars’ Group 2017 Annual Meeting | Link |
| May 2017 | Poster Presentation | 7th International Meeting Challenges in Endourology, Paris, France | Link |
| April 2017 | Oral Presentation | ASIT Conference 2017, Bournemouth, UK | Link |
| March 2017 | Poster Presentation | European Association of Urology (EAU) 2017 Annual Meeting, London, UK | Abstract |
MIMIC Collaborators
Evidence for all collaborators
List of MIMIC Collaborators
| Hospital | Collaborators |
| Addenbrooke’s Hospital | Nicholas Ivin, Jonathan Maw, Ali Abdaal, Cissy |
| Austin Hospital, Heidelberg, Victoria, Australia | Todd Manning, Daniel Christidis |
| Barts Health, Whipps Cross and the Royal London | Shahid Khan, Sibel Demirel |
| Bendigo Health, Australia | Samantha Koschel, Henry Badgery |
| Box Hill Hospital, Melbourne, Australia | Luke Luoke Wang, Tatenda Calvin Nzenza |
| Broomfield Hospital | Ruzi Begum, Shazia Hamad, Aarti Shetty |
| Charing Cross Hospital | Hamid Abboudi, Rozh Jalil |
| Cheltenham General Hospital | Cherrie Wing Yin Ho, Iram Parwaiz |
| Chester Hospital, Mersey | Fraser Cameron, Connie Shingles |
| Craigavon Area Hospital, Northern Ireland | Jessica S. Morrow, David Curry |
| Cumberland Infirmary Carlisle | Kenneth Russell MacKenzie, Kyle Reid |
| Darent Valley Hospital | Nazrin Assaf, Adekinte Oyekan |
| Dorset County Hospital, Dorchester | Zara Hayat , Victoria Morrison-Jones |
| Edinburgh | Alexander Laird, Abhishek D Sharma |
| Fiona Stanley Hospital, Perth, Western Australia | Simeon Ngweso, Munyaradzi Nyandoro |
| Forth Valley Royal hospital | Jane Hendry, Lynne Kerr |
| Freeman hospital, newcastle | Andrew Harris |
| Glasgow Royal Infirmary | Flora Rodger, Emma Docherty, Guat Shi Ng |
| Great Western Hospital, Swindon | Haitham Abdelmoteleb |
| Guys Hospital | David Eldred-Evans |
| Harlow Hospital, Princess Alexandra Hospital | Thomas Stonier, Nick Simson, Harpreet Kaur Sekhon Inderjit SIngh, Emer Hatem |
| Heart of England NHS FT (Birmingham) | Rebecca Tregunna |
| Heidelberg Repatriation Hospital, Australia | Shannon McGrath, Jonathan O’Brien |
| High Wycombe Hospital | Angus Campbell, Peter Linton Cronbach |
| James Cook University Hospital, Middlesborough | Arjun Nambier, Campbell D Tait |
| James Paget University Hospital, Great Yarmouth | Lokesh Suraparaju, James W O’Brien |
| Kettering General Hospital | Rahul Pankhania |
| King’s College Hospital | Robert Foley, Abisoye Akintimehin |
| Kingston Hospital | Monika Rezacova, Eric Edison |
| LEICESTER GENERAL HOSPITAL | Nkwam Nkwam, Peter Grice |
| Lister hospital, Stevenage | Florence Kashora, Osayuki Nehikhare, Nadine McCauley |
| Luton and Dunstable hospital | Kishan Tailor |
| Manchester Royal Infirmary | Angus Chin On Luk |
| Maroondah Hospital, Eastern Health | Christopher Steen, Matthew Alberto |
| Musgrove Park Hospital Taunton | James Olivier, Joel Tay |
| Norfolk and Norwich | Jack Coode-Bate, Madhavi Natarajan |
| North Manchester General Hospital | James Akman |
| Northampton General Hospital | Kevin Murtagh, Anne Carrie |
| Northwick Park / Central Middlesex | Nishant Bedi |
| Nottingham Univeristy Hospitals | Manar Malki, Frances Burge |
| Peterborough City Hospital | Iannish Sadien, Iqbal Miakhil |
| Princess Royal Hospital Haywards Heath | Patrick Olaniyi, Roelof Joe Stammeijer, Hannah Mason |
| Queen Alexandra Hospital, Portsmouth | Lisa Lavan |
| Queen Elizabeth Hospital, Birmingham | Carol Wong, Sarah Al-Shakhshir |
| Queen Elizabeth Hospital, Kings Lynn | Wesam Al-Dhahir, Mohamed Ahmed Abdelhafiz Abu Yousif, |
| Rotherham general hospital | Li June Tay, A. E. Ward |
| Royal Alexandria Hospital, Paisley, Scotland | Alastair Crawford McKay |
| Royal Devon and Exeter hospital | L.A.M Simmons, S Khadhouri |
| Royal Free Hospital | John Withington |
| Royal United Hospitals Bath | Jonathan Lee Chuo Min |
| Salford | Matthew Liew, Richard Simpson |
| Sheffield | Marcus G Cumberbatch, Karl H Pang |
| Southend University Hospital | Robert Adams, Asfand Baig Mirza |
| Southmead Hospital/Severn Deanery | Johnson Pok-Him Tam, Edward Tudor |
| St George’s Hospital, London | Michael Gallagher, Yaamini Premakumar, Michael Ager |
| St James’s University Hospital, Leeds | Andrei Adrian Kozan, Ata Jaffer, Waqas Din |
| St Vincent’s University Hospital in Dublin, Ireland | Mudit Matanhelia, Stephen Moyles |
| Sunderland | Daniel Ness |
| Torbay and Devon | Kellie Bateman |
| Ulster Hospital, Belfast, Northern Ireland | Joshua Michael Clements, Gemma Hann, Catherine Gilmore |
| University College London Hospital | Ben Lamb, Gidon Ellis, Chuanyu Gao |
| University Hospital of South Manchester | Laura Derbyshire |
| Unversity Hospital Wales | Rebecca Mosey, Banan Osman |
| Wellington Hospital, New Zealand | Omid Yassaie, George Weeratunga |
| Western Heatlh Australia | Cristian Udovicich |
| Weston Super Mare | Su-Min Lee, Ali Hussain |
| Whiston Hospital, Merseyside | James Mbuvi, Heather Stewart |
| Whittington Hospital | Taimur Shah, Archie Hughes-Hallet |
| Wigan Infirmary | Sean AF Rezvani , Shawn Ooi Peng Sheng |
| Worthing Hospital, Western Sussex NHS Trust | Francesca Kum, Rebecca Symes |
| Wrexham Maelor Hospital | Issam Ahmed |
